Dealing with itchy pimples? Typically, inflammation and redness are associated with acne. However, secondary skin conditions like dryness, sensitivity, and a compromised moisture barrier can make your pimples itch. When dealing with this kind of acne, you want to proceed a little differently than what you usually do to treat pimples. Instead of applying a hot compress and using topical ingredients that can be over-drying, it's best to gently decrease inflammation with an ice cube and wash your face with a non-foaming cleanser. And no matter how tempting, the primary thing you should avoid is scratching at the affected area.